Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 9/20 | 0.40 |
| ▸ | SLC2A3 | P11169 | 9/20 | 0.40 |
| ▸ | SLC2A4 | P14672 | 8/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SLC2A2 | P11168 | 3/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13683148 | 0.80 | GAA (0.44) | CCR1KDM4ERECQLLMNASMN1; SMN2 | |
| SCHEMBL15334767 | 0.71 | KDM4E (0.37) | KDM4ERECQLNLRP3MAPT | |
| SCHEMBL23090407 | 0.70 | DHODH (0.49) | CCR1SLC2A1SLC2A3SLC2A4LMNA | |
| SCHEMBL13184171 | 0.70 | KDM4E (0.36) | CCR1KDM4ERECQLNLRP3MAPT | |
| SCHEMBL1008520 | 0.69 | MAPT (0.64) | LMNASMN1; SMN2MAPT | |
| SCHEMBL8323814 | 0.68 | KDM4E (0.39) | KDM4ERECQLSLC2A1LMNANLRP3 | |
| SCHEMBL13754852 | 0.68 | KDM4E (0.36) | KDM4ERECQLLMNASMN1; SMN2NLRP3 | |
| SCHEMBL17066930 | 0.68 | MAPT (0.47) | CCR1KDM4ERECQLLMNASMN1; SMN2 | |
| SCHEMBL13748687 | 0.67 | KDM4E (0.35) | KDM4ERECQL | |
| SCHEMBL8324291 | 0.66 | SMN1; SMN2 (0.38) | CCR1KDM4ERECQLLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |