Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13715589 | 0.85 | P2RX7 (0.38) | P2RX7KDM4ERECQLTDP1 | |
| SCHEMBL13715746 | 0.85 | P2RX7 (0.37) | P2RX7KDM4ERECQLPOLB | |
| SCHEMBL13184174 | 0.76 | GRIA2 (0.35) | P2RX7GRIA2POLB | |
| SCHEMBL14044079 | 0.75 | P2RX7 (0.34) | P2RX7 | |
| SCHEMBL24080848 | 0.74 | P2RX7 (0.35) | P2RX7KDM4ERECQL | |
| SCHEMBL2873510 | 0.73 | HCAR2 (0.34) | P2RX7 | |
| SCHEMBL2874012 | 0.73 | P2RX7 (0.30) | P2RX7 | |
| SCHEMBL2874348 | 0.70 | PDK2 (0.31) | PDK2 | |
| SCHEMBL13184191 | 0.70 | NOTUM (0.33) | P2RX7 | |
| SCHEMBL2876634 | 0.69 | NOTUM (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7435831-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |