Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3371658 | 0.90 | GRM5 (0.67) | GRM5 | |
| SCHEMBL6135652 | 0.84 | GRM5 (0.59) | GRM5 | |
| SCHEMBL4700139 | 0.82 | GRM5 (0.65) | GRM5 | |
| SCHEMBL4699537 | 0.82 | GRM5 (0.65) | GRM5 | |
| SCHEMBL13683937 | 0.81 | GRM5 (0.61) | GRM5 | |
| SCHEMBL13683876 | 0.80 | GRM5 (0.66) | GRM5 | |
| SCHEMBL13683875 | 0.80 | GRM5 (0.62) | GRM5 | |
| SCHEMBL13068916 | 0.80 | GRM5 (0.80) | GRM5 | |
| SCHEMBL4698815 | 0.80 | GRM5 (0.65) | GRM5 | |
| SCHEMBL13683913 | 0.79 | GRM5 (0.75) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592337-B2 | Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5 | MERCK & CO., INC. (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592337-B2 | Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5 | MERCK & CO., INC. (US) | 2009-09-22 | — | — | US | disclosed |