Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3371658 | 0.93 | GRM5 (0.67) | GRM5 | |
| SCHEMBL3371020 | 0.90 | GRM5 (0.65) | GRM5 | |
| SCHEMBL4700139 | 0.88 | GRM5 (0.65) | GRM5 | |
| SCHEMBL13684154 | 0.84 | GRM5 (0.60) | GRM5 | |
| SCHEMBL4699537 | 0.81 | GRM5 (0.65) | GRM5 | |
| SCHEMBL4701864 | 0.80 | GRM5 (0.67) | GRM5 | |
| SCHEMBL4698815 | 0.79 | GRM5 (0.65) | GRM5 | |
| SCHEMBL4703812 | 0.77 | GRM5 (0.63) | GRM5 | |
| SCHEMBL4699189 | 0.77 | GRM5 (0.65) | GRM5 | |
| SCHEMBL13683937 | 0.76 | GRM5 (0.61) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485093-A4 | DI-ARYL SUBSTITUTED TETRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2005-12-28 | — | — | EP | disclosed |
| EP-1485093-A1 | DI-ARYL SUBSTITUTED TETRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | Merck & Co., Inc. (US) | 2004-12-15 | — | — | EP | disclosed |
| WO-2003077918-A1 | DI-ARYL SUBSTITUTED TETRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO., INC. (US) | 2003-09-25 | — | — | WO | disclosed |