Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LIPA | P38571 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7777844 | 0.73 | LIPA (0.54) | EPHX1APOBEC3AAPOBEC3GHTTKDM4E | |
| SCHEMBL11058892 | 0.71 | EPHX2 (0.39) | EPHX1MAPTEPHX2 | |
| SCHEMBL13008729 | 0.69 | LIPA (0.50) | EPHX1APOBEC3AAPOBEC3GHTTKDM4E | |
| SCHEMBL11960583 | 0.67 | OPRL1 (0.42) | EPHX1APOBEC3AAPOBEC3GHTTSMN1; SMN2 | |
| SCHEMBL18334865 | 0.67 | CYP19A1 (0.42) | EPHX1APOBEC3AAPOBEC3GHTTKDM4E | |
| SCHEMBL14436583 | 0.66 | SMN1; SMN2 (0.49) | EPHX1KDM4ESMN1; SMN2MAPTGAA | |
| SCHEMBL10267770 | 0.66 | SMN1; SMN2 (0.49) | EPHX1KDM4ESMN1; SMN2MAPTGAA | |
| SCHEMBL7112401 | 0.66 | TSHR (0.39) | EPHX1APOBEC3AAPOBEC3GHTTKDM4E | |
| SCHEMBL2657093 | 0.66 | SMN1; SMN2 (0.49) | EPHX1KDM4ESMN1; SMN2MAPTGAA | |
| SCHEMBL24425896 | 0.66 | CYP4F2 (0.35) | SMN1; SMN2GAAEPHX2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2522669-A1 | 3-Spirocyclic indolyl derivatives useful as ORL-1 receptor modulators | Janssen Pharmaceutica NV (BE) | 2012-11-14 | — | — | EP | disclosed |