Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 13/20 | 0.58 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4993791 | 0.87 | MET (0.59) | METRPS6KA3KDM4EALDH1A1MAPT | |
| SCHEMBL4989561 | 0.83 | MET (0.47) | METRPS6KA3KDM4EALDH1A1MAPT | |
| SCHEMBL1414765 | 0.83 | MET (0.66) | METRPS6KA3KDM4EALDH1A1MAPT | |
| Bay-474 SCHEMBL4994862 | 0.83 | MET (0.66) | METRPS6KA3KDM4EALDH1A1MAPT | |
| SCHEMBL9888390 | 0.82 | MET (0.51) | METRPS6KA3KDM4EALDH1A1MAPT | |
| SCHEMBL2009550 | 0.81 | MET (0.58) | METRPS6KA3KDM4EALDH1A1MAPT | |
| SCHEMBL4992471 | 0.81 | MET (0.50) | METRPS6KA3KDM4EALDH1A1MAPT | |
| SCHEMBL4994508 | 0.81 | MET (0.45) | METRPS6KA3KDM4EALDH1A1MAPT | |
| SCHEMBL2009485 | 0.81 | MET (0.63) | METRPS6KA3KDM4EALDH1A1MAPT | |
| SCHEMBL4988283 | 0.81 | MET (0.63) | METRPS6KA3KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121608-B1 | DIHYDROPYRIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | BAYER IP GMBH (DE) | 2012-11-14 | — | — | EP | disclosed |