Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13685408 | 0.96 | MEN1 (0.41) | KMT2AMEN1LMNAGLAHSP90AA1 | |
| Succinic Acid SCHEMBL13685431 | 0.95 | KMT2A (0.41) | KMT2AMEN1LMNAGLAHSP90AA1 | |
| SCHEMBL13685321 | 0.95 | PTPN1 (0.43) | KMT2AMEN1LMNAHSP90AA1HSP90AB1 | |
| SCHEMBL2585059 | 0.95 | PTPN1 (0.43) | KMT2AMEN1LMNAHSP90AA1HSP90AB1 | |
| Succinic Acid SCHEMBL13685421 | 0.92 | PTGDR2 (0.37) | KMT2AMEN1LMNAHSP90AA1HSP90AB1 | |
| Succinic Acid SCHEMBL13685368 | 0.91 | PTPN1 (0.39) | KMT2AMEN1LMNAHSP90AA1HSP90AB1 | |
| Succinic Acid SCHEMBL2587201 | 0.91 | PTPN1 (0.39) | KMT2AMEN1LMNAHSP90AA1HSP90AB1 | |
| SCHEMBL2586316 | 0.89 | ALDH1A1 (0.46) | KMT2AMEN1SMN1; SMN2HPGDHTR2A | |
| SCHEMBL13685333 | 0.87 | MEN1 (0.40) | KMT2AMEN1HSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL12160346 | 0.87 | MEN1 (0.40) | KMT2AMEN1HSP90AA1HSP90AB1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680091-B2 | 6-arylalkylamino-2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists | ELI LILLY AND COMPANY (US) | 2014-03-25 | — | — | US | claimed |
| EP-1924561-B1 | 6-ARYLALKYLAMINO- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | LILLY CO ELI (US) | 2012-11-14 | — | — | EP | claimed |