Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | TERF2 | Q15554 | 6/20 | 0.31 |
| ▸ | BIRC3 | Q13489 | 3/20 | 0.31 |
| ▸ | XIAP | P98170 | 2/20 | 0.31 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13685689 | 0.83 | TERF2 (0.34) | TERF2BIRC3XIAPBIRC2 | |
| SCHEMBL13685681 | 0.81 | TERF2 (0.34) | TERF2BIRC3XIAPBIRC2 | |
| SCHEMBL13685776 | 0.81 | TERF2 (0.41) | HDAC6HDAC3HDAC1TERF2BIRC3 | |
| SCHEMBL13685695 | 0.79 | TERF2 (0.41) | TERF2BIRC3XIAPBIRC2 | |
| SCHEMBL13685613 | 0.78 | TERF2 (0.34) | HDAC6HDAC3HDAC1TERF2BIRC3 | |
| SCHEMBL13685775 | 0.78 | HDAC1 (0.42) | HDAC6HDAC3HDAC1TERF2BIRC3 | |
| SCHEMBL13685682 | 0.77 | TERF2 (0.36) | TERF2BIRC3XIAPBIRC2 | |
| SCHEMBL13685680 | 0.77 | TERF2 (0.43) | TERF2BIRC3XIAPBIRC2 | |
| SCHEMBL13685734 | 0.75 | TERF2 (0.32) | TERF2BIRC3XIAPBIRC2 | |
| SCHEMBL8291503 | 0.73 | F2 (0.41) | HDAC6HDAC3HDAC1F2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592419-B2 | Macrocyclic inhibitors of hepatitis C virus NS3-serine protease | SCHERING CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592419-B2 | Macrocyclic inhibitors of hepatitis C virus NS3-serine protease | SCHERING CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |