TERF2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL29779770	0.53	9/20
SCHEMBL12856031	0.39	8/20
SCHEMBL22105950	0.38	7/20
SCHEMBL22677610	0.38	7/20
SCHEMBL17888971	0.34	7/20
SCHEMBL17992357	0.39	6/20
SCHEMBL21335115	0.39	6/20
SCHEMBL30818425	0.34	6/20
SCHEMBL30818426	0.34	6/20
SCHEMBL19532409	0.49	5/20
SCHEMBL14952656	0.48	5/20
SCHEMBL17413318	0.46	5/20
SCHEMBL14971405	0.44	5/20
SCHEMBL21335300	0.44	5/20
SCHEMBL22106077	0.44	5/20
SCHEMBL17992333	0.43	5/20
SCHEMBL22105904	0.43	5/20
SCHEMBL22678340	0.42	5/20
SCHEMBL22429493	0.39	5/20
SCHEMBL22429645	0.39	5/20

Clinical trials — most relevant to TERF2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Nandrolone Decanoate in the Treatment of Telomeropathies	PHASE1/PHASE2	COMPLETED
Low-Dose Danazol for the Treatment of Telomere Related Diseases	PHASE2	COMPLETED
Danazol for Genetic Bone Marrow and Lung Disorders	PHASE1/PHASE2	COMPLETED
Danazol for Treatment of Cytopenias in Patients With Cirrhosis	PHASE2	RECRUITING
Imetelstat for Children With Refractory or Recurrent Solid Tumors and Lymphoma	PHASE1	WITHDRAWN
Nucleoside Therapy in Patients With Telomere Biology Disorders	PHASE1	RECRUITING
Telomeres Length in Israeli Fibrotic ILD Patients	nan	ENROLLING_BY_INVITATION
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility	nan	RECRUITING
Telomere Disclosure and Impact on Psychological Distress and Health Behaviors	nan	COMPLETED
Telomere and Telomerase	nan	WITHDRAWN
Body Awareness and Aerobic Exercise: Telomere Impact	nan	COMPLETED
Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants	nan	RECRUITING
Telomere Repair Gene Mutation in Inflammatory Bowel Disease	nan	COMPLETED
Telomeric Abnormalities in Colorectal Diseases by Fluorescent in Situ Hybridization Technique	nan	UNKNOWN
Anti-age Dietary Supplements in Healthy Older Adults: the proBNPage Reduction Trial	nan	UNKNOWN
Telomerase Activator and Retinal Amyloid	nan	COMPLETED
Aerobic Exercise and Telomere Length in Patients With Heart Failure.	nan	UNKNOWN
Mitochondrial DNA Copy Number and Leukocyte Telomere Length as Biomarkers in Type 2 Diabetic Patients	nan	UNKNOWN
Nasal Brushing for the Diagnosis and Understanding of Telomeropathies	nan	UNKNOWN
Cyclin-dependent Kinase Inhibitor 2A (Placental Senescence Marker) on Labor-related Signals	nan	UNKNOWN
Amplification of Zinc Finger Protein 217 Gene in Multiple Myeloma	nan	UNKNOWN
Chromosomal Translocations in Chandigarh Police	nan	COMPLETED
Self-Directed Biological Transformation Initiative	nan	COMPLETED
Vascular Senescence and Atherosclerotic Plaque Vulnerability	nan	RECRUITING
Natural History of Acquired and Inherited Bone Marrow Failure Syndromes	nan	RECRUITING
Impact of Bariatric and Metabolic Surgery on the Reduction of Premature Aging.	nan	COMPLETED
Impact of Diet and Physical Activity Changes on Body Weight, Biomarkers and Quality of Life in Breast Cancer Survivors	nan	COMPLETED
Influence of Prostate Cancer Radiation on Aging	nan	COMPLETED
Molecular and Clinical Analysis of Bone Marrow Failure: A Secondary Research Study	nan	ENROLLING_BY_INVITATION
Genetic Biomarkers of Executive Stress	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TERF2 binder may also engage these)

Protein	Name	Similarity
O35144	—	1.000	O35144 →
Q9QXM1	—	0.991	Q9QXM1 →
Q32LQ1	—	0.991	Q32LQ1 →
Q8K3I4	—	0.991	Q8K3I4 →
Q8TF30	—	0.988	Q8TF30 →
Q62925	—	0.988	Q62925 →
Q6P1H6	—	0.988	Q6P1H6 →
Q5PQX1	—	0.987	Q5PQX1 →
Q62315	—	0.987	Q62315 →
Q9PU53	—	0.987	Q9PU53 →
Q9Y5B0	—	0.987	Q9Y5B0 →
Q96RY5	—	0.987	Q96RY5 →
Q58CQ0	—	0.987	Q58CQ0 →
Q9ULM0	—	0.986	Q9ULM0 →
Q5HYC2	—	0.986	Q5HYC2 →
Q921T2	—	0.986	Q921T2 →
Q8K136	—	0.986	Q8K136 →
Q7L190	—	0.986	Q7L190 →
Q6ZW76	—	0.986	Q6ZW76 →
SNAPC4	snRNA-activating protein complex subunit 4	0.986	landscape →
Q92833	—	0.986	Q92833 →
Q92543	—	0.986	Q92543 →
E1U8D0	—	0.986	E1U8D0 →
A2A9T0	—	0.986	A2A9T0 →
A6ND36	—	0.985	A6ND36 →
Q6P9J5	—	0.985	Q6P9J5 →
Q501R9	—	0.985	Q501R9 →
Q8N5H7	—	0.985	Q8N5H7 →
Q5JTD0	—	0.985	Q5JTD0 →
Q9Y6A5	—	0.985	Q9Y6A5 →