Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26177798 | 0.79 | AKR1B1 (0.35) | AKR1B1PDE7A | |
| SCHEMBL25761386 | 0.79 | AKR1B1 (0.35) | AKR1B1PDE7A | |
| SCHEMBL14516941 | 0.78 | PDE7A (0.39) | PDE7APDK2PDK4PDK1PDK3 | |
| SCHEMBL3138211 | 0.77 | PDK2 (0.61) | AKR1B1PDE7APDK2PDK4PDK1 | |
| SCHEMBL26978878 | 0.76 | PDK2 (0.48) | AKR1B1PDE7APDK2PDK4PDK1 | |
| SCHEMBL30661815 | 0.76 | PDK2 (0.48) | AKR1B1PDE7APDK2PDK4PDK1 | |
| SCHEMBL844744 | 0.67 | PDK2 (0.57) | AKR1B1PDK2PDK4HTR5AMEN1 | |
| SCHEMBL30242138 | 0.67 | PDK2 (0.57) | AKR1B1PDK2PDK4HTR5AMEN1 | |
| SCHEMBL11730433 | 0.67 | AKR1B1 (0.47) | AKR1B1PDE7APDK2PDK4PDK1 | |
| SCHEMBL26760308 | 0.67 | AKR1B1 (0.47) | AKR1B1PDE7APDK2PDK4PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595338-B2 | Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles | WYETH (US) | 2009-09-29 | — | — | US | disclosed |