Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13685061 | 1.00 | GAA (0.33) | GAAPLGPDE4BBACE1F2 | |
| SCHEMBL13684888 | 1.00 | GAA (0.33) | GAAPLGPDE4BBACE1F2 | |
| SCHEMBL12607419 | 0.92 | CTSD (0.35) | GAABACE1 | |
| SCHEMBL8054841 | 0.91 | MEN1 (0.31) | GAAPLGBACE1F2F10 | |
| SCHEMBL13684911 | 0.88 | BACE1 (0.33) | GAABACE1F2F10PRSS1 | |
| SCHEMBL13684914 | 0.87 | GAA (0.33) | GAABACE1F2F10PRSS1 | |
| SCHEMBL8289664 | 0.86 | GAA (0.32) | GAA | |
| SCHEMBL12606636 | 0.86 | MEN1 (0.34) | GAAPLGBACE1F2F10 | |
| SCHEMBL12606587 | 0.86 | GAA (0.32) | GAABACE1F2F10PRSS1 | |
| SCHEMBL8289601 | 0.85 | GAA (0.38) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592419-B2 | Macrocyclic inhibitors of hepatitis C virus NS3-serine protease | SCHERING CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |