Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.58 |
| ▸ | CHUK | O15111 | 1/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2499552 | 0.88 | IKBKB (0.76) | IKBKBCHUKKDM1AGPR119PDE4B | |
| SCHEMBL19030458 | 0.86 | KDM1A (0.56) | KDM1AGPR119PDE4BPDE4APDE4C | |
| SCHEMBL2496652 | 0.85 | IKBKB (0.55) | IKBKBCHUKGPR119 | |
| SCHEMBL2507279 | 0.85 | IKBKB (0.55) | IKBKBCHUKKDM1AGPR119PDE4B | |
| SCHEMBL18860082 | 0.85 | KDM1A (0.55) | KDM1AGPR119PDE4BPDE4APDE4C | |
| SCHEMBL23360301 | 0.84 | IKBKB (0.54) | IKBKBCHUKGPR119CHEK2 | |
| SCHEMBL29862689 | 0.84 | IKBKB (0.54) | IKBKBCHUKGPR119CHEK2 | |
| SCHEMBL30701894 | 0.83 | GPR119 (0.54) | IKBKBCHUKGPR119CHEK2 | |
| SCHEMBL29862463 | 0.83 | GPR119 (0.54) | IKBKBCHUKGPR119CHEK2 | |
| SCHEMBL2503394 | 0.83 | GPR119 (0.54) | IKBKBCHUKGPR119CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899322-B1 | ISOQUINOLINE DERIVATIVES AS INHIBITORS OF RHO-KINASE | SANOFI AVENTIS (FR) | 2009-09-02 | — | — | EP | disclosed |
| WO-2007000240-A1 | ISOQUINOLINE DERIVATIVES AS INHIBITORS OF RHO-KINASE | SANOFI-AVENTIS (DE) | 2007-01-04 | — | — | WO | disclosed |