Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13689799 | 0.85 | MAPT (0.48) | MAPTCYP1A2CYP2C19CYP2C9HTT | |
| SCHEMBL13689788 | 0.84 | MAPT (0.43) | MAPTCYP1A2CYP2C19CYP2C9HTT | |
| SCHEMBL13689728 | 0.83 | CCR5 (0.34) | CCR5CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL602902 | 0.82 | CHRM2 (0.40) | MAPTCYP1A2CYP2C19CYP2C9HTT | |
| SCHEMBL602903 | 0.82 | CHRM2 (0.40) | MAPTCYP1A2CYP2C19CYP2C9HTT | |
| SCHEMBL600514 | 0.80 | CHRM4 (0.51) | MAPTCYP1A2CYP2C19CYP2C9PKM | |
| SCHEMBL600515 | 0.80 | CHRM4 (0.51) | MAPTCYP1A2CYP2C19CYP2C9PKM | |
| SCHEMBL601263 | 0.79 | CHRM4 (0.54) | MAPTPKMALDH1A1MAPK1RAB9A | |
| SCHEMBL602569 | 0.79 | CHRM4 (0.54) | MAPTPKMALDH1A1MAPK1RAB9A | |
| SCHEMBL601262 | 0.79 | CHRM4 (0.54) | MAPTPKMALDH1A1MAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009110844-A1 | MUSCARINIC RECEPTOR AGONISTS, COMPOSITIONS, METHODS OF TREATMENT THEREOF, AND PROCESSES FOR PREPARATION THEREOF | ASTRAZENECA AB (SE) | 2009-09-11 | — | — | WO | disclosed |