Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 16/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12861202 | 0.78 | KDM4E (0.48) | RET | |
| SCHEMBL1021345 | 0.78 | RET (0.47) | RETPTPN11 | |
| SCHEMBL2424922 | 0.77 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1 | |
| SCHEMBL2424920 | 0.77 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1 | |
| SCHEMBL31726067 | 0.77 | GRIN2D (0.38) | PTPN11GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2425371 | 0.76 | HSP90AA1 (0.51) | RETHSP90AA1HSP90AB1 | |
| SCHEMBL3975551 | 0.76 | HSP90AA1 (0.39) | RETPTPN11MAPK3MAPK1HSP90AA1 | |
| SCHEMBL2424112 | 0.76 | HSP90AA1 (0.52) | RETHSP90AA1HSP90AB1 | |
| SCHEMBL2612628 | 0.76 | GPR119 (0.41) | RET | |
| SCHEMBL1021398 | 0.76 | MAPT (0.52) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009114173-A1 | AZABICYCLO [3. 2. I] OCTYL DERIVATIVES AS 11 BETA-HSDL MODULATORS | EXELIXIS, INC. (US) | 2009-09-17 | — | — | WO | disclosed |