Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 7/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MATK | P42679 | 1/20 | 0.32 |
| ▸ | FRK | P42685 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13693286 | 0.92 | MAPK14 (0.37) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL70235 | 0.77 | BRAF (0.40) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL68118 | 0.72 | CDK8 (0.42) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL67221 | 0.71 | SPR (0.38) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL68130 | 0.70 | MAPK14 (0.40) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL68361 | 0.70 | BRAF (0.40) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL68182 | 0.68 | TLR8 (0.38) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL13693361 | 0.65 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL67180 | 0.62 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL13693369 | 0.62 | MAPK8 (0.47) | MAPK14MAPK13MAPK12MAPK11BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115572-A2 | NOVEL HETEROCYCLIC COMPOUNDS AND USES THEROF | NOVARTIS AG (CH) | 2009-09-24 | — | — | WO | disclosed |