SPR — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1263823	0.54	10/20
SCHEMBL1193113	0.59	9/20
SCHEMBL1174425	0.48	9/20
SCHEMBL309514	0.48	8/20
SCHEMBL942032	0.47	8/20
SCHEMBL308408	0.55	5/20
SCHEMBL829518	0.51	5/20
SCHEMBL3472	0.50	5/20
Hydrochloric Acid (SCHEMBL798115)	0.49	5/20
SCHEMBL333570	0.42	5/20
SCHEMBL574333	0.41	5/20
SCHEMBL1032085	0.38	5/20
SCHEMBL824587	0.35	5/20
Acetylserotonin (SCHEMBL422165)	1.00	4/20
SCHEMBL1131640	0.76	4/20
SCHEMBL1127784	0.70	4/20
Oxalic Acid (SCHEMBL1320479)	0.70	4/20
SCHEMBL798165	0.70	4/20
SCHEMBL803617	0.69	4/20
SCHEMBL1132343	0.69	4/20

Clinical trials — most relevant to SPR by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Tetrahydrobiopterin (BH4) on Leg Blood Flow and Exercise Capacity in Patients With Peripheral Artery Disease	PHASE4	WITHDRAWN
Effects of Statin and Ezetimibe Association on Kinetics of Artificial Chilomicrons	PHASE4	COMPLETED
Clinical Role of Testosterone and Dihydrotestosterone and Which of Them Should be Inhibited in COVID-19 Patients - A Double-edged Sword?	PHASE4	UNKNOWN
The Role of Mineralocorticoid Receptors in Vascular Function	PHASE2/PHASE3	COMPLETED
A Study of PTC923 (CNSA-001) in Primary Tetrahydrobiopterin (BH4) Deficient Participants With Hyperphenylalaninemia	PHASE1/PHASE2	COMPLETED
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis	PHASE2	UNKNOWN
Depletion of Serum Amyloid P Component to Enhance the Immune Response to DNA Vaccination	PHASE1/PHASE2	COMPLETED
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC	PHASE2	COMPLETED
Nitrite Infusion Studies	PHASE1	COMPLETED
The Effect of Antioxidants on Skin Blood Flow-BH4	PHASE1	COMPLETED
Novel Approaches for Improving Vascular Function in Veterans With HFpEF	PHASE1	RECRUITING
Exercise and NO in HFrEF	EARLY_PHASE1	COMPLETED
Uterine Artery Doppler Changes After Vaginal Administration of Isosorbide Mononitrate In Patients With URPL	EARLY_PHASE1	UNKNOWN
Large-scale COVID-19 Population Screening	nan	UNKNOWN
European Survey: Risk of Cyanide Poisoning in Smoke Inhalation	nan	COMPLETED
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients	nan	COMPLETED
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD	nan	UNKNOWN
Macrophage Migration Inhibitory Factor (MIF)- Cardiac Surgery	nan	COMPLETED
Ischemic Preconditioning - Perspectives of Use Vivio/in Vitro Studies	nan	ENROLLING_BY_INVITATION
Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC	nan	COMPLETED
Rapid Test for Detection of the Focus of Infection in Post Neurosurgical Patients.	nan	UNKNOWN
Multi-center Controlled Clinical Trials in Alport Syndrome-A Feasibility Study	nan	COMPLETED
Incidence of Iron Deficiency in Polycythemia Vera (PV) and Association With Disease Features	nan	UNKNOWN
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Efficacy and Safety of Angiotensin II Use in Coronavirus Disease(COVID)-19 Patients With Acute Respiratory Distress Syndrome	nan	UNKNOWN
Proof of Concept Creatine Supplementation for Homocystinuria Study	nan	ACTIVE_NOT_RECRUITING
Genetic Variants and Regulation of Specialized Pro-resolving Mediator	nan	RECRUITING
External Nitric Oxide Measurement Through SNO Degradation	nan	ENROLLING_BY_INVITATION
Epidemiology of Atherosclerosis	nan	COMPLETED
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a SPR binder may also engage these)

Protein	Name	Similarity
Q8R536	—	0.997	Q8R536 →
Q17QK8	—	0.996	Q17QK8 →
P18297	—	0.995	P18297 →
Q64105	—	0.992	Q64105 →
Q7ZY31	—	0.982	Q7ZY31 →
B0BML7	—	0.981	B0BML7 →
Q8R123	—	0.970	Q8R123 →
Q9HAB8	—	0.967	Q9HAB8 →
ABHD11	sn-1-specific diacylglycerol lipase ABHD11	0.965	landscape →
P51976	—	0.965	P51976 →
TARS2	Threonine--tRNA ligase, mitochondrial	0.964	landscape →
Q8K4F5	—	0.964	Q8K4F5 →
A0A1U8CC89	—	0.964	A0A1U8CC89 →
Q86TX2	—	0.964	Q86TX2 →
Q17QW3	—	0.963	Q17QW3 →
O57314	—	0.963	O57314 →
Q9HBH5	—	0.963	Q9HBH5 →
Q9ERI6	—	0.963	Q9ERI6 →
O77667	—	0.963	O77667 →
O95396	—	0.962	O95396 →
A0AAT9JA24	—	0.962	A0AAT9JA24 →
P51661	—	0.962	P51661 →
O43542	—	0.962	O43542 →
Q96LJ7	—	0.962	Q96LJ7 →
Q8WZ82	—	0.962	Q8WZ82 →
Q9BSH5	—	0.961	Q9BSH5 →
Q3SZ16	—	0.961	Q3SZ16 →
HSD17B1	17-beta-hydroxysteroid dehydrogenase type 1	0.961	landscape →
P85971	—	0.961	P85971 →
Q7T012	—	0.961	Q7T012 →