Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.35 |
| ▸ | RAF1 | P04049 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | GCGR | P47871 | 2/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13693257 | 0.92 | MAPK14 (0.38) | BRAFMAPK14CSNK1DJAK3MAPK13 | |
| SCHEMBL69405 | 0.79 | BRAF (0.44) | BRAFMAPK14CSNK1DJAK3MAPK13 | |
| SCHEMBL69317 | 0.78 | EIF2AK2 (0.43) | MAPK14MAPK9KDM4EALDH1A1MAPT | |
| SCHEMBL69361 | 0.77 | GSK3B (0.48) | MAPK14 | |
| SCHEMBL67437 | 0.77 | MAPK14 (0.53) | BRAFMAPK14CSNK1DJAK3MAPK13 | |
| SCHEMBL67602 | 0.77 | MAPK14 (0.52) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL68164 | 0.77 | MAPK14 (0.44) | MAPK14MAPK9KDM4EALDH1A1MAPT | |
| SCHEMBL69049 | 0.77 | PIK3CG (0.52) | MAPK14CSNK1DJAK3MAPK13MAPK12 | |
| SCHEMBL69636 | 0.77 | BRAF (0.52) | BRAFMAPK14CSNK1DJAK3MAPK13 | |
| SCHEMBL13693370 | 0.76 | BRAF (0.51) | BRAFMAPK14CSNK1DJAK3MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115572-A2 | NOVEL HETEROCYCLIC COMPOUNDS AND USES THEROF | NOVARTIS AG (CH) | 2009-09-24 | — | — | WO | disclosed |