Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | GCGR | P47871 | 3/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL68620 | 0.80 | MAPK13 (0.63) | BRAFALOX5GCGRMAPK13MAPK12 | |
| SCHEMBL84223 | 0.75 | BRAF (0.65) | BRAFALOX5RAF1 | |
| SCHEMBL67146 | 0.74 | MAPK13 (0.63) | BRAFALOX5GCGRMAPK13MAPK12 | |
| SCHEMBL67052 | 0.73 | MAPK14 (0.56) | BRAFALOX5GCGRMAPK13MAPK12 | |
| SCHEMBL13693373 | 0.71 | MAPK14 (0.61) | BRAFALOX5GCGRMAPK13MAPK12 | |
| SCHEMBL27584011 | 0.70 | BRAF (0.49) | BRAFALOX5MAPK13MAPK12MAPK11 | |
| SCHEMBL68402 | 0.70 | SMPD3 (0.57) | ALOX5GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL67667 | 0.70 | RAF1 (0.65) | BRAFALOX5GCGRMAPK13MAPK12 | |
| SCHEMBL67376 | 0.70 | ALOX5 (0.65) | BRAFALOX5GCGRMAPK13MAPK12 | |
| SCHEMBL66923 | 0.69 | MAPK11 (0.61) | BRAFALOX5GCGRMAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115572-A2 | NOVEL HETEROCYCLIC COMPOUNDS AND USES THEROF | NOVARTIS AG (CH) | 2009-09-24 | — | — | WO | disclosed |