Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.52 |
| ▸ | JAK1 | P23458 | 8/20 | 0.52 |
| ▸ | JAK3 | P52333 | 8/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.33 |
| ▸ | NQO2 | P16083 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.33 |
| ▸ | WDR5 | P61964 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1369363 | 1.00 | JAK2 (0.52) | JAK2JAK1JAK3PDE10ADGAT1 | |
| SCHEMBL1370783 | 0.91 | JAK2 (0.56) | JAK2JAK1JAK3PDE10AWDR5 | |
| SCHEMBL1372179 | 0.89 | JAK2 (0.49) | JAK2JAK1JAK3PDE10ADGAT1 | |
| SCHEMBL12146510 | 0.83 | JAK2 (0.43) | JAK2JAK1JAK3DGAT1 | |
| SCHEMBL1370692 | 0.83 | JAK2 (0.52) | JAK2JAK1JAK3PDE10ADGAT1 | |
| SCHEMBL1371440 | 0.82 | JAK2 (0.50) | JAK2JAK1JAK3PDE10AWDR5 | |
| SCHEMBL1371441 | 0.81 | JAK2 (0.40) | JAK2JAK1JAK3PDE10AMTNR1A | |
| SCHEMBL1370713 | 0.81 | JAK2 (0.41) | JAK2JAK1JAK3PDE10ADGAT1 | |
| Hydrochloric Acid SCHEMBL1370229 | 0.80 | JAK2 (0.47) | JAK2JAK1JAK3 | |
| Hydrochloric Acid SCHEMBL1370232 | 0.80 | ACHE (0.46) | JAK2JAK1JAK3MTNR1ANQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140155376-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2014-06-05 | — | — | US | disclosed |
| EP-2571880-A1 | PYRROLO [2, 3 - B]PYRAZINE - 7 - CARBOXAMIDE DERIVATIVES AND THEIR USE AS JAK AND SYK INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144585-A1 | PYRROLO [2, 3 - B] PYRAZINE - 7 - CARBOXAMIDE DERIVATIVES AND THEIR USE AS JAK AND SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-24 | — | — | WO | disclosed |
| US-20110288067-A1 | Pyrrolopyrazine Kinase Inhibitors | HENDRICKS ROBERT THAN (US) | 2011-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288067-A1 | Pyrrolopyrazine Kinase Inhibitors | SYK, ZAP70, JAK2 | JAK2 3/4885JAK1 5/4885JAK3 7/4885 |
| US-20140155376-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | SYK, ZAP70, JAK2 | JAK2 3/4885JAK1 5/4885JAK3 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.