Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.81 |
| ▸ | MAOA | P21397 | 3/20 | 0.81 |
| ▸ | POLB | P06746 | 2/20 | 0.79 |
| ▸ | CA12 | O43570 | 2/20 | 0.79 |
| ▸ | CA9 | Q16790 | 2/20 | 0.79 |
| ▸ | F12 | P00748 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717527 | 0.90 | MAOB (1.00) | MAOBMAOAPOLBCA12CA9 | |
| SCHEMBL2036575 | 0.89 | MAOB (0.74) | MAOBMAOAPOLBCA12CA9 | |
| SCHEMBL31206250 | 0.88 | MAOB (0.77) | MAOBMAOAPOLBCA12CA9 | |
| SCHEMBL11481128 | 0.88 | MAOB (0.77) | MAOBMAOAPOLBCA12CA9 | |
| SCHEMBL5190662 | 0.88 | POLB (1.00) | MAOBMAOAPOLBCA12CA9 | |
| SCHEMBL27951961 | 0.85 | CA12 (0.74) | MAOBMAOAPOLBCA12CA9 | |
| SCHEMBL28015505 | 0.84 | PPARG (0.68) | MAOBMAOAPOLBCA12CA9 | |
| SCHEMBL11473080 | 0.84 | F12 (0.88) | MAOBMAOAPOLBCA12CA9 | |
| Propene SCHEMBL27951962 | 0.83 | MAOB (0.85) | MAOBMAOAPOLBCA12CA9 | |
| SCHEMBL7672880 | 0.82 | CA12 (0.69) | MAOBMAOAPOLBCA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067461-B2 | 3-acyl coumarins, thiochromones and quinolones and therapeutic uses thereof | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2011-11-29 | — | — | US | disclosed |
| US-20090275650-A1 | 3-Acyl coumarins, thiochromones and quinolones and therapeutic uses thereof | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2009-11-05 | — | — | US | disclosed |
| WO-2006132947-A2 | 3-ACYL COUMARINS, THIOCHROMONES AND QUINOLONES AND THERAPEUTIC USES THEREOF | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2006-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275650-A1 | 3-Acyl coumarins, thiochromones and quinolones and therapeutic uses thereof | NQO2, NQO1, HCCS | MAOB 2929/4885MAOA 3570/4885POLB 2722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.