Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 3/20 | 0.57 |
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13698435 | 0.87 | KDM4E (0.76) | KDM4ETSHRALDH1A1MEN1KMT2A | |
| SCHEMBL13698434 | 0.86 | KDM4E (0.74) | KDM4ETSHRALDH1A1MEN1KMT2A | |
| SCHEMBL13698425 | 0.85 | KDM4E (1.00) | KDM4ETSHRALDH1A1MEN1KMT2A | |
| SCHEMBL13698558 | 0.85 | KDM4E (0.65) | KDM4ETSHRALDH1A1MEN1KMT2A | |
| SCHEMBL13698440 | 0.84 | KDM4E (0.71) | KDM4ETSHRALDH1A1MEN1KMT2A | |
| SCHEMBL3453593 | 0.83 | KDM4E (0.74) | KDM4ETSHRALDH1A1MEN1KMT2A | |
| SCHEMBL13698542 | 0.81 | KDM4E (0.56) | KDM4ETSHRALDH1A1MEN1KMT2A | |
| SCHEMBL13698510 | 0.81 | KDM4E (0.56) | KDM4ETSHRALDH1A1MEN1KMT2A | |
| SCHEMBL3977661 | 0.81 | KDM4E (0.71) | KDM4ETSHRALDH1A1MEN1KMT2A | |
| SCHEMBL13698416 | 0.80 | KDM4E (0.66) | KDM4ETSHRALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11517568-B2 | Compounds and methods for treating nematode infections | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2022-12-06 | — | — | US | disclosed |
| US-20200405710-A1 | COMPOUNDS AND METHODS FOR TREATING NEMATODE INFECTIONS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2020-12-31 | — | — | US | disclosed |
| US-20090239873-A1 | Phenyl-piperazine derivatives as modulators of muscarinic receptors | BLANCO MIGUEL GARCIA-GUZMAN | 2009-09-24 | — | — | US | disclosed |
| US-7563795-B2 | Phenyl-piperazine derivatives as modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-07-21 | — | — | US | disclosed |
| US-7563795-B2 | Phenyl-piperazine derivatives as modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200405710-A1 | COMPOUNDS AND METHODS FOR TREATING NEMATODE INFECTIONS | HNMT, HRH2, NISCH | KDM4E 3975/4885TSHR 3568/4885ALDH1A1 619/4885 |
| US-20090239873-A1 | Phenyl-piperazine derivatives as modulators of muscarinic receptors | CHRM3, CHRM5, CHRM2 | KDM4E 2199/4885TSHR 98/4885ALDH1A1 2270/4885 |
| US-11517568-B2 | Compounds and methods for treating nematode infections | HNMT, HRH2, NISCH | KDM4E 3975/4885TSHR 3568/4885ALDH1A1 619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.