Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557986 | 1.00 | ALDH1A1 (0.52) | ALDH1A1GAAMAPTMAPK1HTT | |
| Hydrochloric Acid SCHEMBL3273754 | 0.98 | ALDH1A1 (0.54) | ALDH1A1GAAMAPTMAPK1HTT | |
| SCHEMBL3275466 | 0.90 | ALDH1A1 (0.47) | ALDH1A1GAAMAPTMAPK1HTT | |
| SCHEMBL13699537 | 0.90 | ALDH1A1 (0.47) | ALDH1A1GAAMAPTMAPK1HTT | |
| SCHEMBL13891162 | 0.90 | HTT (0.50) | ALDH1A1GAAMAPTMAPK1HTT | |
| SCHEMBL4164073 | 0.90 | ALDH1A1 (0.47) | ALDH1A1GAAMAPTMAPK1HTT | |
| SCHEMBL13891221 | 0.90 | HTT (0.50) | ALDH1A1GAAMAPTMAPK1HTT | |
| Hydrochloric Acid SCHEMBL3279850 | 0.88 | ALDH1A1 (0.49) | ALDH1A1GAAMAPTMAPK1HTT | |
| SCHEMBL9641990 | 0.88 | KDM4E (0.54) | ALDH1A1MAPTTSHRMEN1KMT2A | |
| SCHEMBL4407771 | 0.88 | AOC3 (0.53) | ALDH1A1TSHRMEN1KMT2AAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221582-A1 | Piperazine Derivatives And Their Use In Therapy | VERNALIS (R&D) (GB) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221582-A1 | Piperazine Derivatives And Their Use In Therapy | CNR2, CNR1, ALK | ALDH1A1 1066/4885GAA 3365/4885MAPT 3800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.