Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | BCHE | P06276 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8271779 | 0.85 | PTGER4 (0.47) | PTGER4ALDH1A1BCHESMN1; SMN2LMNA | |
| SCHEMBL6638954 | 0.84 | NPC1 (0.48) | ALDH1A1BCHESMN1; SMN2LMNAHTT | |
| SCHEMBL28799972 | 0.84 | BCHE (0.54) | BCHEACHE | |
| SCHEMBL6641148 | 0.83 | ALDH1A1 (0.44) | PTGER4ALDH1A1BCHESMN1; SMN2LMNA | |
| SCHEMBL22450720 | 0.82 | PTGER4 (0.52) | PTGER4ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL10184024 | 0.80 | NPC1 (0.52) | ALDH1A1BCHESMN1; SMN2LMNAHTT | |
| SCHEMBL29071621 | 0.78 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2LMNAHTTNPC1 | |
| SCHEMBL17829696 | 0.78 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| SCHEMBL4350898 | 0.78 | PTGER4 (0.43) | PTGER4ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL1093666 | 0.76 | ALDH1A1 (0.66) | PTGER4ALDH1A1NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2105164-A1 | Novel P2X7R antagonists and their use | Affectis Pharmaceuticals AG (DE) | 2009-09-30 | — | — | EP | disclosed |