Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 18/20 | 0.61 |
| ▸ | IL1B | P01584 | 16/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1020129 | 0.90 | P2RX7 (0.64) | P2RX7IL1BNPC1RAB9A | |
| SCHEMBL12955100 | 0.89 | P2RX7 (0.52) | P2RX7IL1BNPC1RAB9A | |
| SCHEMBL1021922 | 0.88 | P2RX7 (0.61) | P2RX7IL1BNPC1RAB9A | |
| SCHEMBL1019208 | 0.88 | P2RX7 (0.61) | P2RX7IL1BNPC1RAB9A | |
| SCHEMBL13672903 | 0.88 | P2RX7 (0.59) | P2RX7IL1BNPC1RAB9A | |
| SCHEMBL13673000 | 0.86 | P2RX7 (0.59) | P2RX7IL1BNPC1RAB9A | |
| SCHEMBL1019225 | 0.85 | P2RX7 (0.70) | P2RX7IL1B | |
| SCHEMBL1019676 | 0.85 | P2RX7 (0.70) | P2RX7IL1B | |
| SCHEMBL1018984 | 0.84 | P2RX7 (0.68) | P2RX7IL1B | |
| SCHEMBL1019096 | 0.82 | P2RX7 (0.59) | P2RX7IL1BNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2105164-A1 | Novel P2X7R antagonists and their use | Affectis Pharmaceuticals AG (DE) | 2009-09-30 | — | — | EP | disclosed |