Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | IL1B | P01584 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1020668 | 0.88 | PDE10A (0.51) | PDE10AP2RX7NPC1RAB9AMEN1 | |
| SCHEMBL1018854 | 0.88 | PDE10A (0.51) | PDE10AP2RX7NPC1RAB9AMEN1 | |
| SCHEMBL12955100 | 0.88 | P2RX7 (0.52) | PDE10AP2RX7NPC1RAB9AMEN1 | |
| SCHEMBL13673128 | 0.85 | PDE10A (0.51) | PDE10AP2RX7NPC1RAB9AMEN1 | |
| SCHEMBL1020143 | 0.83 | CNR1 (0.56) | PDE10AP2RX7CNR1IL1B | |
| SCHEMBL1019066 | 0.82 | PDE10A (0.52) | PDE10AP2RX7NPC1RAB9AMEN1 | |
| SCHEMBL1019950 | 0.81 | NPC1 (0.57) | PDE10AP2RX7NPC1RAB9AIL1B | |
| SCHEMBL13672956 | 0.81 | PDE10A (0.51) | PDE10AP2RX7NPC1MEN1KMT2A | |
| SCHEMBL1020731 | 0.81 | PDE10A (0.51) | PDE10AP2RX7NPC1RAB9AMEN1 | |
| SCHEMBL1020250 | 0.79 | PDE10A (0.53) | PDE10AP2RX7NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2105164-A1 | Novel P2X7R antagonists and their use | Affectis Pharmaceuticals AG (DE) | 2009-09-30 | — | — | EP | disclosed |