Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 6/20 | 0.51 |
| ▸ | HRH1 | P35367 | 6/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4685418 | 0.85 | KMT2A (0.57) | HRH2HRH1MAPK1ALDH1A1LMNA | |
| SCHEMBL4677918 | 0.85 | MAPK1 (0.52) | HRH2HRH1MAPK1ALDH1A1LMNA | |
| SCHEMBL8238788 | 0.82 | CACNA1B (0.46) | HRH2HRH1ALDH1A1TSHRCTSK | |
| SCHEMBL13701594 | 0.81 | CACNA1B (0.48) | ALDH1A1TSHRCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL1706174 | 0.79 | MAPK1 (0.55) | HRH2HRH1MAPK1ALDH1A1LMNA | |
| SCHEMBL12535753 | 0.79 | MAPK1 (0.55) | HRH2HRH1MAPK1ALDH1A1LMNA | |
| SCHEMBL1706172 | 0.79 | MAPK1 (0.55) | HRH2HRH1MAPK1ALDH1A1LMNA | |
| SCHEMBL7352660 | 0.78 | MAPK1 (0.54) | HRH2HRH1MAPK1ALDH1A1LMNA | |
| SCHEMBL27432720 | 0.78 | CACNA2D1 (0.48) | MAPK1ALDH1A1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL27308696 | 0.76 | CACNA2D1 (0.47) | MAPK1ALDH1A1CACNA2D1CACNA1BCACNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221603-A1 | HETEROCYCLIC AMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | ZALICUS PHARMACEUTICALS LTD. (CA) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221603-A1 | HETEROCYCLIC AMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | RYR2, CACNA1E, RYR1 | HRH2 64/4885HRH1 160/4885MAPK1 3026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.