Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | HRH2 | P25021 | 4/20 | 0.48 |
| ▸ | HRH1 | P35367 | 4/20 | 0.48 |
| ▸ | CALCRL | Q16602 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5142485 | 0.89 | CALCRL (0.46) | MAPK1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL4685418 | 0.87 | KMT2A (0.57) | MAPK1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL5891166 | 0.87 | CTSS (0.46) | MAPK1ALDH1A1LMNAKMT2AHRH2 | |
| SCHEMBL5891753 | 0.86 | CALCRL (0.48) | MAPK1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL5891355 | 0.85 | ITGB3 (0.47) | MAPK1KMT2AHRH2HRH1CALCRL | |
| SCHEMBL13701477 | 0.85 | HRH2 (0.51) | MAPK1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL5141586 | 0.84 | CALCRL (0.49) | MAPK1ALDH1A1LMNAKMT2AHRH2 | |
| SCHEMBL5142544 | 0.84 | TSHR (0.59) | KMT2AMEN1CALCRLCTSSCTSK | |
| SCHEMBL5891240 | 0.84 | CTSS (0.51) | KMT2ACALCRLCTSSCTSKTSHR | |
| SCHEMBL5891360 | 0.84 | CALCRL (0.43) | MAPK1ALDH1A1LMNAKMT2AHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409479-B1 | 1-GLYCINYL-4-(1-METHYLPIPERIDIN-4-YL)PIPERAZINES AND -PIPERIDINES AS FACTOR XA ANTAGONISTS | LILLY CO ELI (US) | 2008-01-23 | — | — | EP | disclosed |
| US-7265121-B2 | Chemical compounds | ELI LILLY AND COMPANY (US) | 2007-09-04 | — | — | US | disclosed |
| US-20050026928-A1 | Chemical compounds | ELI LILLY AND COMPANY | 2005-02-03 | — | — | US | disclosed |
| EP-1409479-A2 | 1-GLYCINYL-4-(1-METHYLPIPERIDIN-4-YL)PIPERAZINES AND -PIPERIDINES AS FACTOR XA ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003010160-A2 | 1-GLYCINYL-4 (METHYLPIPERIDIN-4-YL) PIPERAZINES AND -PIPERRIDINES AS FACTOR XA ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2003-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026928-A1 | Chemical compounds | F2, F12, F11 | MAPK1 2581/4885ALDH1A1 1389/4885LMNA 1275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.