Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 9/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | HRH2 | P25021 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4293624 | 0.93 | HCRTR1 (0.37) | MAPTKDM4EHCRTR1HCRTR2USP2 | |
| SCHEMBL4284611 | 0.92 | HCRTR1 (0.37) | KDM4EHCRTR1HCRTR2PDE4BHSD11B1 | |
| SCHEMBL13705164 | 0.91 | HCRTR1 (0.36) | MAPTKDM4EHCRTR1HCRTR2PDE4B | |
| SCHEMBL13705273 | 0.90 | HCRTR1 (0.36) | MAPTHCRTR1HCRTR2DRD3PDE4B | |
| SCHEMBL13705268 | 0.89 | HCRTR1 (0.35) | KDM4EHCRTR1HCRTR2PDE4BHSD11B1 | |
| SCHEMBL13705272 | 0.88 | HCRTR1 (0.34) | MAPTKDM4EHCRTR1HCRTR2USP2 | |
| SCHEMBL13705153 | 0.87 | HCRTR1 (0.37) | HCRTR1HCRTR2ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL4292787 | 0.86 | HCRTR1 (0.37) | MAPTKDM4EHCRTR1HCRTR2USP2 | |
| SCHEMBL13705165 | 0.86 | HCRTR1 (0.35) | HCRTR1HCRTR2PDE4BHSD11B1 | |
| SCHEMBL13705160 | 0.86 | PARP1 (0.32) | HCRTR1HCRTR2PDE4BHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227560-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-10 | — | — | US | disclosed |
| US-20090156612-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
| US-20090156612-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156612-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | MAPT 3142/4885KDM4E 760/4885HCRTR1 3147/4885 |
| US-20090227560-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | MAPT 3142/4885KDM4E 760/4885HCRTR1 3147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.