Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | BCL9 | O00512 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13705338 | 0.95 | CXCR4 (0.42) | CXCR4SMN1; SMN2NPC1RAB9APDE4B | |
| SCHEMBL4860535 | 0.89 | SMN1; SMN2 (0.47) | CXCR4SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL4860543 | 0.89 | SMN1; SMN2 (0.47) | CXCR4SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL13340760 | 0.89 | SMN1; SMN2 (0.47) | CXCR4SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL4285458 | 0.86 | KDM4E (0.41) | KDM4EALDH1A1MEN1KMT2ASIGMAR1 | |
| SCHEMBL8125847 | 0.86 | PDE4B (0.49) | CXCR4SMN1; SMN2NPC1RAB9APTGDR2 | |
| SCHEMBL13705349 | 0.86 | GPR183 (0.45) | CXCR4SMN1; SMN2NPC1RAB9APTGDR2 | |
| SCHEMBL8124047 | 0.86 | GPR183 (0.43) | CXCR4SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL8113714 | 0.85 | PDE4B (0.43) | CXCR4SMN1; SMN2NPC1RAB9APTGDR2 | |
| SCHEMBL13705354 | 0.85 | CXCR4 (0.43) | CXCR4SMN1; SMN2NPC1RAB9ABCL9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227560-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-10 | — | — | US | disclosed |
| US-20090227560-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227560-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | CXCR4 3648/4885SMN1; SMN2 4811/4885NPC1 1165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.