Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | GPR183 | P32249 | 1/20 | 0.44 |
| ▸ | BCL9 | O00512 | 3/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.41 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 4/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | YAP1 | P46937 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8113703 | 0.92 | PARP1 (0.52) | PARP1BCL9CTNNB1PDK1PDK2 | |
| SCHEMBL13705543 | 0.90 | PARP1 (0.53) | PARP1GPR183BCL9CTNNB1PDK1 | |
| SCHEMBL8123475 | 0.90 | PARP1 (0.55) | PARP1BCL9CTNNB1PDK1PDK2 | |
| SCHEMBL4860080 | 0.90 | PARP1 (0.58) | PARP1BCL9CTNNB1PDK1PDK2 | |
| SCHEMBL4860072 | 0.90 | PARP1 (0.58) | PARP1BCL9CTNNB1PDK1PDK2 | |
| SCHEMBL13340759 | 0.90 | PARP1 (0.58) | PARP1BCL9CTNNB1PDK1PDK2 | |
| SCHEMBL13705325 | 0.88 | PARP1 (0.52) | PARP1BCL9CTNNB1PDK1PDK2 | |
| SCHEMBL8122210 | 0.88 | PARP1 (0.51) | PARP1BCL9CTNNB1PDK1PDK2 | |
| SCHEMBL8112397 | 0.88 | PARP1 (0.54) | PARP1PDK1PDK2PDK3PDK4 | |
| SCHEMBL8123342 | 0.87 | PARP1 (0.52) | PARP1BCL9CTNNB1PDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227560-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-10 | — | — | US | disclosed |
| US-20090156612-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156612-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | PARP1 3523/4885GPR183 949/4885BCL9 4342/4885 |
| US-20090227560-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | PARP1 3523/4885GPR183 949/4885BCL9 4342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.