Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 15/20 | 0.68 |
| ▸ | CLK1 | P49759 | 10/20 | 0.68 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.64 |
| ▸ | EGFR | P00533 | 4/20 | 0.64 |
| ▸ | AXL | P30530 | 4/20 | 0.64 |
| ▸ | FLT4 | P35916 | 4/20 | 0.64 |
| ▸ | FLT3 | P36888 | 4/20 | 0.64 |
| ▸ | CLK2 | P49760 | 4/20 | 0.64 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.64 |
| ▸ | CAMK2B | Q13554 | 4/20 | 0.64 |
| ▸ | CAMK2G | Q13555 | 4/20 | 0.64 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.64 |
| ▸ | PTK6 | Q13882 | 4/20 | 0.64 |
| ▸ | NTRK3 | Q16288 | 4/20 | 0.64 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.64 |
| ▸ | MINK1 | Q8N4C8 | 4/20 | 0.64 |
| ▸ | PRKD2 | Q9BZL6 | 4/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13705612 | 0.87 | CLK4 (0.64) | DYRK1ACLK1NTRK1CLK4PRKD3 | |
| SCHEMBL13705600 | 0.85 | PRKD3 (0.63) | DYRK1ACLK1NTRK1CLK4PRKD3 | |
| SCHEMBL14236068 | 0.85 | BRAF (0.53) | DYRK1ACLK1NTRK1CLK4PRKD3 | |
| SCHEMBL13705602 | 0.85 | BTK (0.62) | DYRK1ACLK1NTRK1CLK4PRKD3 | |
| SCHEMBL13705606 | 0.84 | PRKD3 (0.58) | DYRK1ACLK1NTRK1CLK4PRKD3 | |
| SCHEMBL13705556 | 0.84 | PRKD3 (0.61) | DYRK1ACLK1NTRK1CLK4PRKD3 | |
| SCHEMBL13705611 | 0.83 | BTK (0.59) | DYRK1ACLK1NTRK1CLK4PRKD3 | |
| SCHEMBL13705580 | 0.81 | BRAF (0.64) | DYRK1ACLK1NTRK1CLK4PRKD3 | |
| SCHEMBL13705558 | 0.81 | PRKD3 (0.56) | DYRK1ACLK1NTRK1CLK4PRKD3 | |
| SCHEMBL1772392 | 0.81 | BRAF (0.75) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111278-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2009-09-11 | — | — | WO | disclosed |