Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.62 |
| ▸ | AXL | P30530 | 5/20 | 0.62 |
| ▸ | FLT4 | P35916 | 5/20 | 0.62 |
| ▸ | FLT3 | P36888 | 5/20 | 0.62 |
| ▸ | CLK2 | P49760 | 5/20 | 0.62 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.62 |
| ▸ | CAMK2B | Q13554 | 5/20 | 0.62 |
| ▸ | CAMK2G | Q13555 | 5/20 | 0.62 |
| ▸ | CAMK2D | Q13557 | 5/20 | 0.62 |
| ▸ | PTK6 | Q13882 | 5/20 | 0.62 |
| ▸ | NTRK3 | Q16288 | 5/20 | 0.62 |
| ▸ | PKN2 | Q16513 | 5/20 | 0.62 |
| ▸ | MINK1 | Q8N4C8 | 5/20 | 0.62 |
| ▸ | PRKD2 | Q9BZL6 | 5/20 | 0.62 |
| ▸ | SLK | Q9H2G2 | 5/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.62 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13705600 | 0.85 | PRKD3 (0.63) | BTKPRKD3MAP4K4NTRK1AXL | |
| SCHEMBL13705608 | 0.85 | DYRK1A (0.68) | BTKPRKD3MAP4K4NTRK1AXL | |
| SCHEMBL13705611 | 0.84 | BTK (0.59) | BTKPRKD3MAP4K4NTRK1AXL | |
| SCHEMBL1772473 | 0.83 | BRAF (0.71) | BRAF | |
| SCHEMBL13705612 | 0.83 | CLK4 (0.64) | BTKPRKD3MAP4K4NTRK1AXL | |
| SCHEMBL13705558 | 0.80 | PRKD3 (0.56) | BTKPRKD3MAP4K4NTRK1AXL | |
| SCHEMBL13705606 | 0.80 | PRKD3 (0.58) | BTKPRKD3MAP4K4NTRK1AXL | |
| SCHEMBL13705556 | 0.80 | PRKD3 (0.61) | BTKPRKD3MAP4K4NTRK1AXL | |
| SCHEMBL13705609 | 0.79 | CDK1 (0.54) | BTKPRKD3MAP4K4NTRK1AXL | |
| SCHEMBL13705620 | 0.78 | BRAF (0.49) | BTKPRKD3MAP4K4NTRK1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111278-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2009-09-11 | — | — | WO | disclosed |