Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 9/20 | 0.73 |
| ▸ | PDE5A | O76074 | 3/20 | 0.64 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3579453 | 0.88 | PDE9A (0.78) | PDE9APDE5AGRIA1GRIA2GRIA3 | |
| SCHEMBL3599970 | 0.84 | PDE9A (0.80) | PDE9APDE5AMEN1POLBKMT2A | |
| SCHEMBL3492217 | 0.84 | PDE9A (1.00) | PDE9APDE5AGRIA1GRIA2GRIA3 | |
| SCHEMBL3592989 | 0.84 | PDE9A (0.80) | PDE9APDE5AMEN1POLBKMT2A | |
| SCHEMBL3591571 | 0.84 | PDE9A (0.72) | PDE9APDE5AGRIA1GRIA2GRIA3 | |
| SCHEMBL3599726 | 0.82 | PDE9A (0.84) | PDE9APDE5AMEN1POLBKMT2A | |
| SCHEMBL3606047 | 0.82 | PDE9A (0.81) | PDE9APDE5AGRIA1GRIA2GRIA3 | |
| SCHEMBL3593184 | 0.82 | PDE9A (0.77) | PDE9APDE5AAURKAJAK2JAK1 | |
| SCHEMBL3591498 | 0.82 | PDE9A (0.72) | PDE9APDE5AMEN1POLBKMT2A | |
| SCHEMBL3599103 | 0.81 | PDE9A (0.78) | PDE9APDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2103613-A1 | QUINOXALINE DERIVATIVE | ASKA Pharmaceutical Co., Ltd. (JP) | 2009-09-23 | — | — | EP | disclosed |