Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 3/20 | 0.34 |
| ▸ | JAK3 | P52333 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1370078 | 0.90 | ACKR3 (0.42) | ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL1370431 | 0.89 | DGAT1 (0.39) | DGAT1JAK2JAK1JAK3NPC1 | |
| SCHEMBL1368820 | 0.88 | DGAT1 (0.35) | DGAT1JAK2JAK1JAK3CYP4F2 | |
| SCHEMBL1369607 | 0.86 | MEN1 (0.41) | DGAT1ALDH1A1KDM4EKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL1371455 | 0.84 | PBK (0.42) | DGAT1 | |
| SCHEMBL27889101 | 0.82 | DGAT1 (0.36) | DGAT1JAK2JAK1JAK3MAPK1 | |
| SCHEMBL1371116 | 0.82 | JAK2 (0.50) | DGAT1JAK2JAK1JAK3 | |
| SCHEMBL2384175 | 0.80 | DGAT1 (0.40) | DGAT1JAK2JAK1JAK3 | |
| SCHEMBL1352450 | 0.80 | DGAT1 (0.39) | DGAT1ALDH1A1KDM4EJAK2JAK1 | |
| SCHEMBL1352864 | 0.79 | HDAC4 (0.45) | ALDH1A1KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110288067-A1 | Pyrrolopyrazine Kinase Inhibitors | HENDRICKS ROBERT THAN (US) | 2011-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288067-A1 | Pyrrolopyrazine Kinase Inhibitors | SYK, ZAP70, JAK2 | DGAT1 4772/4885ALDH1A1 4484/4885KDM4E 749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.