Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 2/20 | 0.34 |
| ▸ | CLK3 | P49761 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13824662 | 0.84 | PARP1 (0.41) | PARP1CYP11B1CYP1A2CYP11B2NPY5R | |
| SCHEMBL8283777 | 0.83 | CYP1A2 (0.50) | CYP11B1CYP1A2CYP11B2NPY5RPKN2 | |
| SCHEMBL13707022 | 0.83 | CYP2C19 (0.42) | PARP1CYP11B1GRM5 | |
| SCHEMBL13707070 | 0.83 | GRM5 (0.41) | PARP1CYP11B1CYP11B2NPY5RBTK | |
| SCHEMBL4330065 | 0.81 | GRM5 (0.48) | PARP1CYP11B1CYP1A2CYP11B2NPY5R | |
| SCHEMBL13706983 | 0.77 | USP2 (0.39) | CYP11B1CYP1A2CYP11B2NPY5RPKN2 | |
| SCHEMBL13824564 | 0.74 | ALDH1A1 (0.45) | CYP11B1CYP1A2CYP11B2KMT2A | |
| SCHEMBL4433682 | 0.73 | PRKDC (0.45) | CYP11B1CYP1A2CYP11B2PARP10PARP11 | |
| SCHEMBL4431180 | 0.71 | MKNK1 (0.48) | CYP11B1CYP1A2CYP11B2MAPT | |
| SCHEMBL13707059 | 0.70 | PARP10 (0.43) | CYP11B1CYP11B2PARP10PARP11GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227582-A1 | Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-09-10 | — | — | US | disclosed |
| US-7550482-B2 | Tetrahydroquinolones and their use as modulators of metabotropic glutamate receptors | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227582-A1 | Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors | GRM1, GRM5, GRM2 | PARP1 4453/4885CYP11B1 1583/4885CYP1A2 2874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.