Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 7/20 | 0.38 |
| ▸ | MELK | Q14680 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4476832 | 0.87 | USP30 (0.46) | ALDH1A1POLBUSP30MELKMAPT | |
| SCHEMBL3831527 | 0.86 | USP30 (0.51) | USP30 | |
| SCHEMBL3824051 | 0.85 | USP30 (0.44) | ALDH1A1POLBUSP30MELKMAPT | |
| SCHEMBL4467624 | 0.84 | USP30 (0.43) | ALDH1A1POLBUSP30MELKMAPT | |
| SCHEMBL4477957 | 0.81 | USP30 (0.47) | ALDH1A1POLBUSP30MELKMAPT | |
| SCHEMBL3818264 | 0.81 | USP30 (0.41) | ALDH1A1POLBUSP30MELKMAPT | |
| SCHEMBL4484019 | 0.80 | ALDH1A1 (0.47) | ALDH1A1POLBMELKMAPTGAA | |
| SCHEMBL4473863 | 0.79 | USP30 (0.45) | ALDH1A1POLBUSP30MELKMAPT | |
| SCHEMBL4485824 | 0.79 | USP30 (0.45) | ALDH1A1POLBUSP30MELKMAPT | |
| SCHEMBL4469283 | 0.79 | MELK (0.41) | ALDH1A1POLBUSP30MELKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |