Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | VCP | P55072 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | MELK | Q14680 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3816601 | 0.84 | MEN1 (0.41) | IKBKBKMT2AMEN1POLBMAPK1 | |
| SCHEMBL3821234 | 0.78 | MEN1 (0.43) | KMT2AMEN1POLBMAPK1RAB9A | |
| SCHEMBL3819258 | 0.77 | ALDH1A1 (0.54) | IKBKBKMT2AMEN1POLBMAPK1 | |
| SCHEMBL3816421 | 0.73 | MELK (0.41) | KMT2APOLBALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4475686 | 0.72 | ALDH1A1 (0.45) | KMT2AMEN1MAPK1RAB9AALDH1A1 | |
| SCHEMBL4473963 | 0.72 | CYP1A2 (0.46) | KMT2AMEN1POLBRAB9AALDH1A1 | |
| SCHEMBL3824051 | 0.71 | USP30 (0.44) | KMT2APOLBMAPK1ALDH1A1MAPT | |
| SCHEMBL4467624 | 0.71 | USP30 (0.43) | POLBMAPK1RAB9AALDH1A1MAPT | |
| SCHEMBL4475531 | 0.71 | USP30 (0.47) | KMT2AMEN1POLBMAPK1ALDH1A1 | |
| SCHEMBL13711809 | 0.71 | MELK (0.39) | KMT2AMEN1POLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |