Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 3/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 4/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13708555 | 0.92 | HTR2B (0.40) | MDM2HTR2BHTR7BACE1TP53 | |
| SCHEMBL13708578 | 0.88 | BACE1 (0.35) | BACE1SLC9A1KDM4E | |
| SCHEMBL13708556 | 0.87 | SLC9A1 (0.32) | SLC9A1MCL1KDM4EFFAR1 | |
| SCHEMBL13708566 | 0.87 | FFAR1 (0.34) | HTR2BSLC9A1P2RX7HPGDFFAR1 | |
| SCHEMBL13708537 | 0.85 | FFAR1 (0.37) | HTR2BHTR7KCNA5HPGDFFAR1 | |
| SCHEMBL13708553 | 0.85 | DNMT1 (0.33) | SLC9A1MCL1 | |
| SCHEMBL13708564 | 0.85 | PARP10 (0.33) | — | |
| SCHEMBL13708559 | 0.84 | SLC9A1 (0.35) | BACE1TP53SLC9A1 | |
| SCHEMBL4479423 | 0.84 | MDM2 (0.47) | MDM2TP53P2RX7MCL1KDM4E | |
| SCHEMBL13708619 | 0.83 | MDM2 (0.41) | MDM2HTR2BHTR7BACE1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589117-B2 | Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-09-15 | — | — | US | disclosed |
| US-7589117-B2 | Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-09-15 | — | — | US | disclosed |