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Sugi Predict / Targets / SLC9A1

SLC9A1

Sodium/hydrogen exchanger 1 · P19634 · SLC9A1 on Sugi Atlas →

31,243 patent compounds predicted against SLC9A1, 14,334 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL825717 SCHEMBL825717 1.00 20/20
SCHEMBL825753 SCHEMBL825753 1.00 20/20
SCHEMBL825755 SCHEMBL825755 1.00 20/20
SCHEMBL825759 SCHEMBL825759 1.00 20/20
SCHEMBL825760 SCHEMBL825760 1.00 20/20
SCHEMBL825775 SCHEMBL825775 1.00 20/20
SCHEMBL825789 SCHEMBL825789 1.00 20/20
SCHEMBL825790 SCHEMBL825790 1.00 20/20
SCHEMBL825795 SCHEMBL825795 1.00 20/20
SCHEMBL825801 SCHEMBL825801 1.00 20/20
SCHEMBL825894 SCHEMBL825894 1.00 20/20
SCHEMBL825896 SCHEMBL825896 1.00 20/20
SCHEMBL825912 SCHEMBL825912 1.00 20/20
SCHEMBL825950 SCHEMBL825950 1.00 20/20
SCHEMBL825952 SCHEMBL825952 1.00 20/20
SCHEMBL825953 SCHEMBL825953 1.00 20/20
SCHEMBL825958 SCHEMBL825958 1.00 20/20
SCHEMBL825969 SCHEMBL825969 1.00 20/20
SCHEMBL826005 SCHEMBL826005 1.00 20/20
SCHEMBL826016 SCHEMBL826016 1.00 20/20

Clinical trials — most relevant to SLC9A1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study PHASE4RECRUITING
Effect of the Use of Dapagliflozin in Patients With Refractory Heart Failure PHASE4RECRUITING
Applying Proton Pump Inhibitor to Prevent and Treat Acute Fluctuating Hearing Loss in Patients With SLC26A4 Mutation PHASE2/PHASE3UNKNOWN
Efficacy and Safety of Tigerase® vs. Pulmozyme® in Patients With Cystic Fibrosis PHASE3COMPLETED
Secretin in Ex-situ Liver Perfusion PHASE1/PHASE2ENROLLING_BY_INVITATION
Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor PHASE2COMPLETED
CHED - Congenital Hereditary Endothelial Dystrophy: New Paradigm Shift in Therapy Using Topical Eye Drops PHASE2UNKNOWN
Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial) PHASE2RECRUITING
Safety and Pharmacokinetic Profiles of Two Formulations of CO-1.01 in Patients With Advanced Solid Tumors PHASE1COMPLETED
Proof of Principle Study for an Efficacy Trial of Linaclotide for Cystic Fibrosis EARLY_PHASE1RECRUITING
POTASSIUM-RICH SALT SUBSTITUTES IN KIDNEY TRANSPLANT RECIPIENTS nanNOT_YET_RECRUITING
Oxalate and Citrate in Humans - Response to Citrate nanRECRUITING
Lithium Countertransport and Blood Pressure In CARDIA and TOMHS nanCOMPLETED
Central Sodium Sensing: Implications for Blood Pressure Regulation nanCOMPLETED
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy nanCOMPLETED
Sodium Transport: Genetics and Hypertension nanCOMPLETED
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts nanCOMPLETED
Effect of Hypertonic Sodium Chloride on Urinary Biomarkers in Healthy Subjects and Patients With Chronic Kidney Disease nanCOMPLETED
SLC13A5 Deficiency Natural History Study - Remote Only nanENROLLING_BY_INVITATION
Prevalence and Risk Factors of Nephrocalcinosis in Children at Sohag University Hospital nanUNKNOWN
SLC13A5 Deficiency Natural History Study - United States Only nanENROLLING_BY_INVITATION
Blood Pressure Control in Juveniles - Longitudinal Study nanCOMPLETED
Incidence of Renal Tubular Acidosis in Nephrology Unit in Assiut University Childern Hospital nanUNKNOWN
The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Healthy Humans. nanCOMPLETED
Comparison Between Ultra-low-dose Computed Tomography and Lung MRI in Cystic Fibrosis nanCOMPLETED
Clinical Phenotypic Characteristics of SC26A4 nanUNKNOWN
Identifying Diuretic Resistance in Patients With Acute Heart Failure nanCOMPLETED
Hereditary Tubulointerstitial Nephritis nanCOMPLETED
Primary Nasal Cell Culture as a Tool for Personalized Therapy in Cystic Fibrosis nanCOMPLETED
Cardiovascular Effects of Empagliflozine nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a SLC9A1 binder may also engage these)

ProteinNameSimilarity
P48761 — 1.000 P48761 →
P48762 — 1.000 P48762 →
Q28036 — 1.000 Q28036 →
Q61165 — 1.000 Q61165 →
P26431 — 0.998 P26431 →
P23791 — 0.998 P23791 →
A1L3P4 — 0.995 A1L3P4 →
P48763 — 0.994 P48763 →
P26434 — 0.993 P26434 →
SLC9A2 Sodium/hydrogen exchanger 2 0.993 landscape →
Q3ZAS0 — 0.992 Q3ZAS0 →
Q01345 — 0.992 Q01345 →
Q8BUE1 — 0.992 Q8BUE1 →
Q8BLV3 — 0.991 Q8BLV3 →
P50482 — 0.991 P50482 →
Q96T83 — 0.988 Q96T83 →
Q6AI14 — 0.986 Q6AI14 →
D4A7H1 — 0.985 D4A7H1 →
F7B113 — 0.985 F7B113 →
D3ZJ86 — 0.985 D3ZJ86 →
P26432 — 0.984 P26432 →
Q92581 — 0.983 Q92581 →
Q8IVB4 — 0.982 Q8IVB4 →
SLC9A3 Sodium/hydrogen exchanger 3 0.980 landscape →
B2RXE2 — 0.980 B2RXE2 →
O16452 — 0.976 O16452 →
Q6U841 — 0.976 Q6U841 →
Q8RWU6 — 0.976 Q8RWU6 →
P35524 — 0.976 P35524 →
P35449 — 0.976 P35449 →