Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1062189 | 0.90 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPK1 | |
| SCHEMBL1062301 | 0.88 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPK1 | |
| SCHEMBL1055314 | 0.86 | KDM4E (0.49) | ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL1058274 | 0.86 | KDM4E (0.50) | ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL1061747 | 0.85 | SMN1; SMN2 (0.44) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPK1 | |
| SCHEMBL1062302 | 0.85 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPK1 | |
| SCHEMBL1059795 | 0.84 | KDM4E (0.51) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPK1 | |
| SCHEMBL1057562 | 0.84 | SMN1; SMN2 (0.43) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPK1 | |
| SCHEMBL1063432 | 0.84 | SMN1; SMN2 (0.43) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPK1 | |
| SCHEMBL1061996 | 0.84 | DRD3 (0.43) | ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247588-B1 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2016-04-13 | — | — | EP | disclosed |
| WO-2009107850-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-03 | — | — | WO | disclosed |