Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19331724 | 0.92 | HPGD (0.43) | EPHX1HPGDALDH1A1MEN1MAPT | |
| SCHEMBL15025983 | 0.87 | GAA (0.40) | EPHX1HPGDALDH1A1MEN1MAPT | |
| SCHEMBL19342170 | 0.86 | HPGD (0.43) | EPHX1HPGDALDH1A1MEN1MAPT | |
| SCHEMBL13871751 | 0.86 | EPHX1 (0.44) | EPHX1HPGDALDH1A1MEN1MAPT | |
| SCHEMBL21748946 | 0.85 | HPGD (0.46) | EPHX1HPGDALDH1A1MEN1MAPT | |
| SCHEMBL12492477 | 0.85 | HPGD (0.46) | EPHX1HPGDALDH1A1MEN1MAPT | |
| SCHEMBL12493100 | 0.85 | HPGD (0.46) | EPHX1HPGDALDH1A1MEN1MAPT | |
| SCHEMBL25568092 | 0.85 | HPGD (0.46) | EPHX1HPGDALDH1A1MEN1MAPT | |
| SCHEMBL3893868 | 0.84 | EPHX1 (0.44) | EPHX1HPGDALDH1A1MEN1MAPT | |
| SCHEMBL9938535 | 0.84 | PDE4B (0.43) | EPHX1HPGDALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699797-B1 | PYRROLOTRIAZINE COMPOUNDS AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-09-23 | — | — | EP | disclosed |