Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 10/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13709374 | 0.92 | VDR (0.40) | VDRHDAC6HDAC3ARHDAC1 | |
| SCHEMBL14086434 | 0.85 | VDR (0.41) | VDRHDAC6HDAC3ARHDAC1 | |
| SCHEMBL13709376 | 0.84 | VDR (0.46) | VDRHDAC6HDAC3AR | |
| SCHEMBL13709375 | 0.83 | VDR (0.41) | VDRHDAC6HDAC3AR | |
| SCHEMBL13709368 | 0.76 | HDAC3 (0.55) | VDRHDAC6HDAC3ARHDAC1 | |
| SCHEMBL13709377 | 0.74 | ESR1 (0.34) | VDRHDAC6HDAC3ARSRD5A1 | |
| SCHEMBL13709372 | 0.74 | ESR1 (0.32) | VDRHDAC6HDAC3AR | |
| SCHEMBL13709294 | 0.74 | PPARA (0.38) | VDRHDAC6HDAC3ARHDAC1 | |
| SCHEMBL13709325 | 0.73 | PPARA (0.40) | VDRHDAC6HDAC3ARHDAC1 | |
| SCHEMBL13709365 | 0.70 | HDAC3 (0.34) | VDRHDAC6HDAC3ARSRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595345-B2 | Vitamin D receptor modulators | ELI LILLY AND COMPANY (US) | 2009-09-29 | — | — | US | disclosed |