Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.63 |
| ▸ | NPC1 | O15118 | 7/20 | 0.63 |
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | HPGD | P15428 | 4/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | ALPL | P05186 | 1/20 | 0.63 |
| ▸ | STAT1 | P42224 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ACP1 | P24666 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.51 |
| ▸ | LCK | P06239 | 6/20 | 0.51 |
| ▸ | ITK | Q08881 | 5/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10271298 | 0.86 | AURKB (0.52) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL139660 | 0.85 | AURKB (0.51) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL141365 | 0.83 | AURKB (0.65) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL137777 | 0.83 | AURKB (0.51) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL140358 | 0.83 | AURKB (0.77) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL140359 | 0.83 | AURKB (0.77) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL140143 | 0.82 | AURKB (0.65) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL139289 | 0.80 | AURKB (0.51) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL138174 | 0.80 | AURKB (0.56) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL144508 | 0.79 | AURKB (0.51) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058984-A1 | PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | US | disclosed |
| US-20120058984-A1 | PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058984-A1 | PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS | DTYMK, ITK, DCK | SMN1; SMN2 4393/4885NPC1 2786/4885RAB9A 3413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.