Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2676020 | 0.80 | KIF11 (0.63) | KIF11S1PR1NPC1PARP10PARP11 | |
| Hydrochloric Acid SCHEMBL2675682 | 0.79 | KIF11 (0.61) | KIF11S1PR1NPC1PARP10PARP11 | |
| SCHEMBL13676215 | 0.76 | TRPV1 (0.45) | KIF11NPC1CASP3RAB9ASENP8 | |
| SCHEMBL13676221 | 0.76 | TRPV1 (0.44) | KIF11NPC1CASP3RAB9ASENP8 | |
| SCHEMBL13676217 | 0.74 | TRPV1 (0.44) | KIF11NPC1CASP3RAB9ASENP8 | |
| SCHEMBL13676216 | 0.74 | EPHX2 (0.43) | KIF11S1PR1NPC1CASP3RAB9A | |
| SCHEMBL4004269 | 0.72 | NPSR1 (0.50) | KIF11NPC1RAB9ATRPV1 | |
| SCHEMBL4001563 | 0.72 | TRPV1 (0.72) | KIF11NPC1CASP3RAB9ASENP8 | |
| SCHEMBL1396703 | 0.72 | KIF11 (0.60) | KIF11S1PR1HRH3PARP10PARP11 | |
| SCHEMBL13676222 | 0.71 | NPC1 (0.43) | KIF11NPC1CASP3RAB9ASENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582657-B2 | Treating inflammatory and neuropathic pain, headache, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, eye disorders, bladder disorders, psoriasis, skin disorders, asthma, herpes simplex | AMGEN INC. (US) | 2009-09-01 | — | — | US | disclosed |
| US-7579347-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2009-08-25 | — | — | US | disclosed |