Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | DRD3 | P35462 | 4/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | HRH2 | P25021 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL334182 | 1.00 | CYP2C9 (0.55) | CYP2C9LMNASLC6A2SLC6A3MAPK1 | |
| SCHEMBL21548014 | 1.00 | CYP2C9 (0.55) | CYP2C9LMNASLC6A2SLC6A3MAPK1 | |
| SCHEMBL22113161 | 1.00 | CYP2C9 (0.55) | CYP2C9LMNASLC6A2SLC6A3MAPK1 | |
| SCHEMBL1573636 | 1.00 | CYP2C9 (0.55) | CYP2C9LMNASLC6A2SLC6A3MAPK1 | |
| SCHEMBL372614 | 1.00 | CYP2C9 (0.55) | CYP2C9LMNASLC6A2SLC6A3MAPK1 | |
| SCHEMBL852253 | 1.00 | CYP2C9 (0.55) | CYP2C9LMNASLC6A2SLC6A3MAPK1 | |
| Hydrochloric Acid SCHEMBL704299 | 0.97 | LMNA (0.52) | CYP2C9LMNASLC6A2SLC6A3MAPK1 | |
| Hydrochloric Acid SCHEMBL7624931 | 0.97 | LMNA (0.52) | CYP2C9LMNASLC6A2SLC6A3MAPK1 | |
| Hydrochloric Acid SCHEMBL1110550 | 0.97 | LMNA (0.52) | CYP2C9LMNASLC6A2SLC6A3MAPK1 | |
| Hydrochloric Acid SCHEMBL3368724 | 0.97 | LMNA (0.52) | CYP2C9LMNASLC6A2SLC6A3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582627-B2 | 3-Amino-7-[3-(1-aminoethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-8-methyl-1H-pyrido[4,3-d]pyrimidine-2,4-dione; quinolone antibiotics; bactericides; for antibiotic- resistant bacterial infections, ciprofloxacin- resistant ones; inhibiting wild-type and quinolone- resistant mutants of DNA gryase | WARNER-LAMBERT COMPANY (US) | 2009-09-01 | — | — | US | disclosed |