Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAP | Q12884 | 19/20 | 0.88 |
| ▸ | DPP4 | P27487 | 18/20 | 0.88 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.88 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.88 |
| ▸ | DPP7 | Q9UHL4 | 11/20 | 0.73 |
| ▸ | PREP | P48147 | 7/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7898224 | 1.00 | FAP (0.88) | FAPDPP4DPP8DPP9DPP7 | |
| SCHEMBL7901017 | 1.00 | FAP (0.88) | FAPDPP4DPP8DPP9DPP7 | |
| SCHEMBL13997343 | 1.00 | FAP (0.88) | FAPDPP4DPP8DPP9DPP7 | |
| Dutogliptin SCHEMBL5502671 | 0.94 | FAP (1.00) | FAPDPP4DPP8DPP9DPP7 | |
| Dutogliptin SCHEMBL164106 | 0.94 | FAP (1.00) | FAPDPP4DPP8DPP9DPP7 | |
| Dutogliptin SCHEMBL5526847 | 0.94 | FAP (1.00) | FAPDPP4DPP8DPP9DPP7 | |
| Dutogliptin SCHEMBL8160917 | 0.94 | FAP (1.00) | FAPDPP4DPP8DPP9DPP7 | |
| Dutogliptin SCHEMBL1236486 | 0.94 | FAP (1.00) | FAPDPP4DPP8DPP9DPP7 | |
| Dutogliptin SCHEMBL8030287 | 0.94 | FAP (1.00) | FAPDPP4DPP8DPP9DPP7 | |
| SCHEMBL8286766 | 0.89 | FAP (0.82) | FAPDPP4DPP8DPP9DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1997533-B1 | Heterocyclic boronic acid compounds, dipeptidyl peptidase IV inhibitors | PHENOMIX CORP (US) | 2014-09-24 | — | — | EP | disclosed |
| US-7576121-B2 | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV | PHENOMIX CORPORATION (US) | 2009-08-18 | — | — | US | disclosed |