FAP

Prolyl endopeptidase FAP · Q12884 · FAP on Sugi Atlas →

63,343 patent compounds predicted against FAP, 31,280 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Dutogliptin Dutogliptin (SCHEMBL164106) 1.00 19/20
Talabostat Talabostat (SCHEMBL393024) 1.00 13/20
SCHEMBL301874 SCHEMBL301874 0.47 12/20
Denagliptin Denagliptin (SCHEMBL682185) 0.67 10/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL295498) 0.80 9/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL356162) 0.80 9/20
SCHEMBL196303 SCHEMBL196303 0.61 9/20
SCHEMBL196304 SCHEMBL196304 0.61 9/20
SCHEMBL196984 SCHEMBL196984 0.61 9/20
SCHEMBL646728 SCHEMBL646728 0.47 9/20
SCHEMBL160189 SCHEMBL160189 0.53 7/20
SCHEMBL637987 SCHEMBL637987 0.49 7/20
SCHEMBL637493 SCHEMBL637493 0.71 6/20
SCHEMBL639988 SCHEMBL639988 0.71 6/20
SCHEMBL464681 SCHEMBL464681 0.55 6/20
Trifluoroacetic Acid Trifluoroacetic Acid (SCHEMBL572193) 0.48 6/20
SCHEMBL636985 SCHEMBL636985 0.61 5/20
SCHEMBL639880 SCHEMBL639880 0.61 5/20
SCHEMBL639502 SCHEMBL639502 0.60 5/20
SCHEMBL554778 SCHEMBL554778 0.68 4/20

Clinical trials — most relevant to FAP by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
68Ga-FAPI-46 PET for Imaging of FAP Expressing Cancer PHASE2COMPLETED
18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection PHASE2RECRUITING
Analyse of Diagnosis Value of Keloid on 68Ga- FAPI-04 PET-CT PHASE1/PHASE2COMPLETED
A Study of 177Lu-FAP-2286 in Advanced Solid Tumors PHASE1/PHASE2RECRUITING
The Diagnostic Accuracy and Clinical Value of FAPI PET in Pleural Mesothelioma PHASE2RECRUITING
Safety Study for the Use of Rapamycin in Children With Familial Adenomatous Polyposis PHASE2NOT_YET_RECRUITING
PET Imaging of Solid Tumors by a Novel Tracer, 68Ga-FAPI PHASE1RECRUITING
FAPI-74 PET/CT in Adults With Fibrosis PHASE1RECRUITING
Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various Cancers PHASE1ACTIVE_NOT_RECRUITING
Imaging of Solid Tumors Using FAP-2286 PHASE1RECRUITING
Diagnosis of Metastatic Tumors on 68Ga-FAPI PET-CT and Radioligand Therapy with 177Lu-EB-FAPI EARLY_PHASE1RECRUITING
68Ga-FAPi-46 PET/CT Scan in Imaging Patients With Sarcoma EARLY_PHASE1ACTIVE_NOT_RECRUITING
Experimental PET Imaging Scans Before Cancer Surgery to Study the Amount of PET Tracer Accumulated in Normal and Cancer Tissues EARLY_PHASE1ACTIVE_NOT_RECRUITING
68Ga-FAPI-04 PET/CT for the Detection of Oral Carcinoma EARLY_PHASE1UNKNOWN
Studying Fibroblast Activity in Patients With Localized Pancreatic Cancer Undergoing Surgery nanCOMPLETED
Quantitative Analysis of 18F-FAPI Dynamic PET/CT for Accurate Differential Diagnosis of MLN of ESCC nanUNKNOWN
[18F]FAPI PET/CT in Suspicious Focal Liver Lesions Without FDG Avidity nanUNKNOWN
Clinical Study of 18F-Labeled FAPI-04 in PET Imaging of Breast Cancer nanRECRUITING
A Novel 68Ga Labeled FAP Ligand PET/CT in Patients With Various Malignant Tumors nanUNKNOWN
The Role of Fibroblast Activation in Uterine Fibroid nanCOMPLETED
Ga-68-FAPI-46 PET for CRC Recurrence Detection in Elevated CEA nanRECRUITING
18F-FAPI and 18F-FDG PET/CT in Patients With Various Types of Cancer nanUNKNOWN
Clinical Application of Fibroblast Activation Protein PET/MRI for Diagnosis and Staging in Malignant Tumors nanUNKNOWN
FAPI Molecular Imaging for Diagnosis of the CMS4 Unfavorable Colorectal Cancer Subtype nanRECRUITING
FAPI PET/CT Prospective Interobserver Agreement nanCOMPLETED
Clinical Study of Trap-(FAPI)3 PET Imaging in the Diagnosis of Pulmonary Nodules nanNOT_YET_RECRUITING
FAPI-PET for Tumor Detection nanRECRUITING
FAP PET/CT or PET/MR Production in the Diagnosis, Staging, and Efficacy Assessment of Malignant Tumors Application nanCOMPLETED
Characterizing Breast Cancer With Al18F-NOTA-FAPI-04 PET/CT (PFB-02) nanUNKNOWN
Early Diagnosis of TTR Amyloidosis by Use of Molecular Biology nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a FAP binder may also engage these)

ProteinNameSimilarity
Q9Z218 1.000 Q9Z218 →
P28843 1.000 P28843 →
A5D7B7 1.000 A5D7B7 →
P0DRB8 0.999 P0DRB8 →
B2D0J4 0.999 B2D0J4 →
B1A4F7 0.999 B1A4F7 →
P42658 0.996 P42658 →
P97321 0.996 P97321 →
Q5IS50 0.996 Q5IS50 →
P22411 0.995 P22411 →
DPP4 Dipeptidyl peptidase 4 0.995 landscape →
O14073 0.995 O14073 →
Q9N2I7 0.993 Q9N2I7 →
Q18253 0.992 Q18253 →
Q6NXK7 0.992 Q6NXK7 →
P14740 0.992 P14740 →
P81425 0.992 P81425 →
B6V868 0.992 B6V868 →
P18962 0.989 P18962 →
Q8N608 0.989 Q8N608 →
Q9P778 0.989 Q9P778 →
P42659 0.988 P42659 →
A1CHP1 0.988 A1CHP1 →
P85841 0.988 P85841 →
Q6Q629 0.987 Q6Q629 →
A0A1Q3EPF5 0.987 A0A1Q3EPF5 →
Q10916 0.987 Q10916 →
P33894 0.986 P33894 →
W4VSJ0 0.986 W4VSJ0 →
Q9VTJ4 0.986 Q9VTJ4 →