Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | POLG | P54098 | 2/20 | 0.61 |
| ▸ | POLA1 | P09884 | 1/20 | 0.61 |
| ▸ | HPRT1 | P00492 | 10/20 | 0.53 |
| ▸ | PNP | P00491 | 4/20 | 0.51 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | VCP | P55072 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004502 | 0.89 | HPRT1 (0.67) | HPRT1PNPBLMMEN1ALDH1A1 | |
| SCHEMBL3861507 | 0.89 | HPRT1 (0.59) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL3861491 | 0.88 | HPRT1 (0.53) | POLBPOLGPOLA1HPRT1PNP | |
| Phosphonic Acid SCHEMBL3861471 | 0.86 | HPRT1 (0.62) | HPRT1PNPBLMMEN1ALDH1A1 | |
| SCHEMBL13714833 | 0.82 | ENPP1 (0.49) | POLBPOLGPOLA1CYP3A4 | |
| SCHEMBL3861483 | 0.82 | HPRT1 (0.56) | HPRT1PNPBLMMEN1ALDH1A1 | |
| SCHEMBL3861499 | 0.81 | HPRT1 (0.61) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL15078256 | 0.81 | POLB (0.66) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL15078165 | 0.80 | POLB (0.73) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL15078160 | 0.78 | POLB (0.72) | POLBPOLGPOLA1HPRT1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579332-B2 | Nucleobase phosphonate analogs for antiviral treatment | GILEAD SCIENCES, INC. (US) | 2009-08-25 | — | — | US | disclosed |
| US-7579332-B2 | Nucleobase phosphonate analogs for antiviral treatment | GILEAD SCIENCES, INC. (US) | 2009-08-25 | — | — | US | disclosed |