SCHEMBL13716248

SCHEMBL13716248

N#Cc1cccc(C(c2ccnc(Cl)n2)C(c2cccnc2)c2cnccn2)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 6/20 0.41
KCNH2 Q12809 2/20 0.41
CYP19A1 P11511 2/20 0.39
CHRNB2 P17787 2/20 0.38
CHRNA5 P30532 2/20 0.38
CHRNA4 P43681 2/20 0.38
VNN1 O95497 1/20 0.38
ALDH1A1 P00352 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
ALOX15 P16050 1/20 0.35
TSHR P16473 1/20 0.35
MAPK1 P28482 1/20 0.35
CYP2C19 P33261 1/20 0.35
HSD17B10 Q99714 1/20 0.35
CLK4 Q9HAZ1 1/20 0.35
CYP17A1 P05093 1/20 0.34
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34
GRM5 P41594 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13716418 0.87 CYP19A1 (0.39) KCNA5KCNH2CYP19A1CHRNB2CHRNA5
SCHEMBL1379187 0.85 KCNA5 (0.40) KCNA5KCNH2CYP19A1CHRNB2CHRNA5
SCHEMBL15005817 0.81 CYP19A1 (0.38) KCNA5KCNH2CYP19A1CHRNB2CHRNA5
SCHEMBL3899464 0.81 VNN1 (0.43) KCNA5KCNH2CYP19A1CHRNB2CHRNA5
SCHEMBL3818719 0.80 CYP19A1 (0.42) KCNA5KCNH2CYP19A1CHRNB2CHRNA5
SCHEMBL3887314 0.80 CYP19A1 (0.42) KCNA5KCNH2CYP19A1CHRNB2CHRNA5
SCHEMBL3810697 0.80 CYP19A1 (0.42) KCNA5KCNH2CYP19A1CHRNB2CHRNA5
SCHEMBL13716204 0.79 S1PR1 (0.37) VNN1CLK4GRM5
SCHEMBL1383218 0.77 VNN1 (0.45) KCNA5KCNH2CYP19A1CHRNB2CHRNA5
SCHEMBL3814522 0.77 VNN1 (0.40) KCNA5KCNH2CYP19A1CHRNB2CHRNA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7569589-B2 Potassium channel inhibitors MERCK & CO., INC. (US) 2009-08-04 US disclosed
US-7569589-B2 Potassium channel inhibitors MERCK & CO., INC. (US) 2009-08-04 US disclosed