Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | DDX3X | O00571 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13363465 | 0.79 | HDAC1 (0.91) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL13972780 | 0.78 | HDAC3 (0.55) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL10113445 | 0.78 | HDAC6 (0.61) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL10113379 | 0.76 | HDAC1 (0.57) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL9168407 | 0.76 | HDAC3 (0.78) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL30021444 | 0.76 | HDAC3 (0.78) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL13716773 | 0.76 | MEN1 (0.46) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL656830 | 0.76 | HDAC3 (0.73) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL1064952 | 0.76 | HDAC1 (1.00) | HDAC6HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL1064957 | 0.76 | HDAC1 (1.00) | HDAC6HDAC1HDAC3HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1249233-B9 | NPYY5 ANTAGONISTS | SHIONOGI & CO (JP) | 2009-08-05 | — | — | EP | disclosed |
| EP-1249233-B1 | NPYY5 ANTAGONISTS | SHIONOGI & CO (JP) | 2008-08-20 | — | — | EP | disclosed |